A new research has
paved the way for an improved individual treatment of the patients with bladder
cancer.
A research team from
Aarhus University Hospital and Aarhus University headed by professor Torben
Ørntoft and professor Lars Dyrskjøt has been in charge of a larger European
research project mapping the molecular mechanisms of early stages of bladder cancer
in 460 patients in Denmark, Sweden, The Netherlands, Germany, Spain and Serbia.
The researchers found
that tumours can be divided into three primary classes with very different
molecular and disease-developing characteristics. These findings may be important
in risk assessment and subsequent choice of treatment.
The researchers found
that bladder tumours from the molecular group with high risk of developing
aggressive disease contain mutations in genes and molecular pathways often
associated with later stages of the disease.
Moreover, the
researchers observed changes in genes involved in genome structure regulation
in 86 percent of the tumours. This new knowledge can facilitate use of new
drugs targeted at these specific changes.
Dyrskjøt said that
this study provides new and valuable insight into the biology of the tumours in
the earliest stages of the disease. Clinical and pathological examinations of
the individual tumours do not always reflect the risk of later disease
aggressiveness.
He added that this
study provides a tool for risk assessment of the patients and thus for
providing optimal treatment.
The study appears in
the journal Cancer Cell.
Representative
Image
Source:
ANI
This is dummy text. It is not meant to be read. Accordingly, it is difficult to figure out when to end it. But then, this is dummy text. It is not meant to be read. Period.
ConversionConversion EmoticonEmoticon